FLiRT a dominant COVID variant responsible for a summer surge in COVID infections (2024)

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Volume 117 Issue 7 July 2024
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Seamas C Donnelly

Editor-in-Chief,

QJM

Email: seamas.donnelly@tcd.ie

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QJM: An International Journal of Medicine, Volume 117, Issue 7, July 2024, Page 483, https://doi.org/10.1093/qjmed/hcae127

Published:

29 July 2024

Article history

Received:

30 June 2024

Published:

29 July 2024

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FLiRT is a COVID variant, specifically a subvariant of JN.1. It gets its name from two specific spike mutations within its structure, namely F to L at position 456 and R to T at position 346. These mutations result in an enhanced transmissible virus with augmented immune evasion capabilities. The QJM has been at the forefront of publishing authoritative reviews on the COVID virus variants throughout the pandemic and subsequently as we learnt to live with this rapidly evolving virus.1–3 We therefore welcome the commentary piece by Dr Kumar and colleagues from the Centre for Global Health, Saveetha Medical College, India highlighting the emerging global challenges of the FLiRT variants. They review the evidence that highlights the greater ability of the FLiRT variants to evade vaccine-induced immunity and their higher effective reproduction number compared to JN.1. This evolving scenario underscores the need for continuous monitoring and adaptive response strategies to address the challenges posed by these evolving new variants.

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